The unprecedented demands for services offered by nurses emerging from the COVID-19 pandemic placed much mental health pressure and physical exhaustion on nurses in the various isolation centers. This study estimated prevalence of anxiety disorder and examined associated factors among nurses working in COVID-19 isolation 
centers in Lagos, Nigeria. A cross-sectional study design was adopted with purposive sampling method selecting two isolation centers in Lagos of total enumeration sample size of 75 nurses was conducted. Data was collected with a validated structured questionnaire and analyzed with IBM SPSS version 25. Fisher’s Exact Test and multivariate logistic regressions were conducted to determine the predictors of anxiety disorders at 5% level of significance and 95% CI. The results showed the mean age of nurses m=37.6 + 10.2 years, while 39.7% of nurses reported having mild to severe anxiety disorder. The age, gender, marital status and living with vulnerable persons were not 
significantly associated with the anxiety disorder with p > 0.05. The odds of anxiety disorder was 2.3 times more likely for nurses having regular contact with COVID-19 patients with symptoms compared to nurses who did not (OR=2.3, 95% CI= 4.338 to 41.962, p=0.010). In conclusion, more than one-third of nurses developed mild to 
severe anxiety disorder. A psychological intervention program is recommended to support the affected nurses.

Keywords: anxiety disorder, coronavirus, isolation centre, nurse, prevalence.