Hesitancy to accept the COVID-19 vaccine has been noted as a public health threat. Despite the benefits of the COVID-19 vaccine, young adults have remained hesitant to accept the vaccine due to insufficient knowledge. This study assessed the knowledge and acceptance of COVID-19 vaccine by young adults in Ibadan North-East local government in Oyo State, Nigeria. The research adopted a cross-sectional study design. The two-stage sampling technique was employed to select 6 wards from the local government. The purposive sampling technique and Cochran formula were used to select 422 young adults. A validated self-administered questionnaire was utilized for data collection; return rate was 90%. Data was analyzed using descriptive statistics, Pearson’s correlation and linear regression at p < 0.05. The mean age of respondents was 24.06  3.51 years. Participants had mean scores of 8.17  1.92 and 5.55  2.06 respectively computed for level of knowledge and acceptance of COVID-19 vaccine. Majority of respondents had a high level of knowledge (340; 88.5%) and high level of acceptance of COVID-19 vaccine (271; 70.6%). There was a significant relationship between knowledge (r = 0.352) and acceptance of COVID-19 vaccine (p < 0.05). Knowledge was a significant predictor variable of acceptance of COVID-19 vaccine (β = .352, t = 7.357, p < 0.01 There is an association between the knowledge regarding the vaccine and acceptance of the COVID-19 vaccine. Thus, vaccine education should be offered in order to sustain the knowledge regarding the vaccine and promote acceptance. 

Keywords: Knowledge, Perception, Acceptance, COVID-19, Vaccine.